Benizelos Rouphos (Greek Μπενιζέλος Ρούφος) was a Greek politician and Prime Minister.
In 1855, Rouphos was elected Mayor of Patra, a post he held for three years. When King Otto of Greece was exiled in 1860, Rouphos became one of three viceroys - along with Konstantinos Kanaris and Dimitrios Voulgaris - that held power from October 10, 1860 until October 19, 1863.
Rouphos served twice as Prime Minister of Greece. He died in 1868