Christos Melissis, (born 1 December 1982) is a Greek football player who currently plays for Panathinaikos FC. He usually plays as a center back but when called upon he is used as a right back or a defensive midfielder.
Towards the end of the 2007–08 season, he was named captain of the PAOK as a reward for his play and commitment.
On 28 July 2008, he transferred to Panathinaikos FC for €2,000,000. He played in 11 games in the 2008–09 season, but his appearances were not convincing and, on August 31, 2009, he was loaned to Larisa FC for one year.