Christos Melissis, (born December 1, 1982 in Edessa) is a Greek football player who currently plays for Thyella Sarakinon. He usually plays as a center back but when called upon he is used as a right back or a defensive midfielder.
Towards the end of the 2007–08 season, he was named captain of the PAOK as a reward for his play and commitment.
On July 28, 2008, he transferred to Panathinaikos for € 2,000,000. He played in 11 games in the 2008–09 season, but his appearances were not convincing and, on August 31, 2009, he was loaned to AEL for one year.
In 2013 he went to Olympiakos Volos to go back to Panthrakikos the next year. In 2016 he joined Veria to leva them the next year for Al-Hilal Omdurman in Sudan. After his spell abroad he returned to Greece to play for Asteras Itea and Thyella Sarakinon.