Bourousis was born in Karditsa, Thessaly, on November 17, 1983. He started playing basketball for local club GS Karditsa before transferring to AEK in 2002. In 2006, he left AEK for Barcelona but later that same year was picked up by Olympiakos on a four-year contract.
He was a member of the 2008 Olympics team. In six Olympic games, the 240lb Bourousis averaged 11.7 points, 5.2 rebounds, and 1.0 steal and impressed the most cynical of Greek fans. He was the second leading scorer on the Hellas team during the Olympics, trailing behind Vassilis Spanoulis’ 14.3 and ahead of bigger names such as Antonis Fotsis (11) and Theodoros Papaloukas (8.8). Boroussis was also second in rebounding after only Fotsis.
Bourousis is a two-time Greek All-star (2006 and 2007) and was named to the 2008-09 All-Euroleague First Team.