The club was established on October 5, 1969 after a merger of two local teams - Aris (established in 1926) and Elpis (established in 1922). It was the re-creation of an older club, with the same name, established in 1930.
The club currently plays at Fourth Division (Group 1).
The club plays its home games at the Municipal Stadium of Drama, which has a capacity of 4,500. The club colours are red and white.
- In 1986, Pandramaikos won the Cup of Amateur Clubs defeating APS Patrai on penalties.
- In 1979, they were runners-up in the same cup, losing on penalties to APO Chios.
- Paraskevas Antzas
- Antonis Kasdovasilis
- Triantafyllos Machairidis
- Charalambos Perperidis
- Yiannis Tsiplakis