Vryzas got his start at Greek sides SKODA Xanthi FC (1992 - 1997) and PAOK before moving on to AC Perugia. From there, he moved to Fiorentina where he had his best years. Later (2006) he signed with AC Torino before moving on to Spain and Celta Vigo. Vryzas returned to Greece in 2007 to play for SKODA Xanthi. After the season ended, he signed once more with PAOK.
Although not a prolific scorer, Vryzas' tenacious work ethic creates chances for his attacking partners with his aerial and passing skills and his ability to hold onto the ball. He was a starter in Greece's victorious Euro 2004 team, scoring a key goal, a fine chip over the keeper, in Greece's 2-1 loss to Russia, which sent the tournament underdogs into the quarterfinal.