Chronopoulou played in a series of plays before her breakthrough in the cinema in 1954. Her first film was entitled "Χαρούμενο ξεκίνημα" (Happy Beginning). It was followed by well-known motion pictures such as: "Τα κόκκινα φανάρια" (Red Lights - 1963), "Κοινωνία ώρα μηδέν" (Society's zero hour - 1966), "Οι θαλασσιές οι χάντρες" (Blue Beads - 1966) and many others. Chronopoulou, on more than one occasion, sang in her films e.g. the song "Έκλαψα χθες" (I cried yesterday) as part of her role as a nightclub singer.