He entered politics in 1961, when he was first elected to the Hellenic Parliament, under the banner of the National Radical Union (ERE) of Constantine Karamanlis. He was reelected since, in all the elections that he has participated in, with ERE and - after 1974 - with New Democracy.
Varvitsiotis has served as Deputy Minister of the Interior (1974), Deputy Minister of Foreign Affairs (1974-1975), Minister for Trade (1975-1977), Minister for Education and Religion (1977-1980), Minister for Justice (1992) and twice as Minister for National Defence.
Varvitsiotis has authored several book on politics and law. He is married with four children.