Tzanetis was born in Smyrna, Asia Minor, in 1918. He was a forward for AEK during the late 1930s and the 1940s, partnering Kleanthis Maropoulos in AEK's front line. Late in his career he was converted into a centre-back by his coach.
During his playing career Tzanetis was capped once by the National Football Team of Greece.
After his playing days were over, Tzanetis took up coaching and was AEK's coach in: 1952, 1955, 1961, 1962 and 1966. In between his stints with AEK he was also coach of the National Team (1960, 1961, 1963, 1964) with a record of 5 wins, 1 draw and 5 losses.
Tzanetis died in 2001