In the next fifty-plus years, he developed himself into the most productive cartoonist in Greece with some 120,000 sketches to his credit.
Christodoulou drew his humourous themes from athletics, politics and every-day life. He was published in newspapers such as Athinaiki, Vradyni, Mesimvrini and such popular magazines as Romantso, Thisavros, Pantheon and Proto.
He also worked with Athlitiki Echo - a sports newspaper, "Makedonia" - a daily published in Northern Greece, etc.
Newspapers would often publish his political sketches on their front page. Even the 7-year rule of the junta could not prevent Christodoulou from expressing his satyrical views of political life in Greece: After the referendum of 1973 to abolish the monarchy, he published a sketch expressing strong doubts as to the authenticity of the official results.
His comical series "The party of the Barrel-ists" («Κόμμα των Βαρελοφρόνων») poked fun both at the political world and the world of the drunks.