Seferiadis was born in Smyrna, Asia Minor, in 1873. He studied Law in France where he obtained his doctorate. Upon return to Smyrna, Seferiadis started writing, winning the "Panionian Award" in 1902 for a collection of poetry. In 1907, he translated Oedipus Rex into demotic Greek causing a major stir amongst the educated people of Smyrna.
Seferiadis also served as legal adviser to the Ministry of the Exterior, under PM Eleftherios Venizelos, as a member of the International Court of the Hague, as a member on the selection committee of Law professors for the University of Thessaloniki, etc.